Infidelity doesn't exactly lend itself to being laugh-out-loud funny, but the project is being touted as in the vein of The Breakup, which obviously had a darker tone than your typical rom-com. That gives me hope for this one. Not to mention, I put a lot of trust in Ron Howard to steer the movie and its subject matter in the right direction.
The film is supposedly set to start filming this Autumn in Vaughn's hometown of Chicago, so they better get casting the leading lady (or ladies). Any ideas about which actress you'd like to see?