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Side Effects of Accutane

Everything You Need to Know About Accutane — 2 Doctors Weigh in on the Side Effects

Have you battled severe acne at any point in your life? Then you may already be familiar with Accutane (known as Roaccutane in Australia). Accutane was a brand name, which is no longer manufactured, for an acne drug called isotretinoin, a derivative of vitamin A, explained Dr. Neal Schultz, a NYC dermatologist and the host of

Dr. Robyn Gmyrek, a dermatologist at Union Square Laser Dermatology, added, "It works by decreasing the amount of oil production released by the sebaceous glands in the skin, [and] has the potential to provide a long-term decrease in acne after a five-month course of medication."

She said that the ideal candidate is someone with severe or scarring acne who has tried — without success — other treatments. Other treatments include topical and oral creams and medications, such as antibiotics, oral contraceptives, and hormonal agents such as spironolactone.

Both Dr. Gymrek and Dr. Schultz worked with POPSUGAR to share the common side effects of Accutane/isotretinoin.

Mild Short-Term Side Effects

Before you begin taking isotretinoin, you should know that a typical treatment plan lasts between three and six months. During those months, it's common to experience the following mild, short-term side effects. The higher your dosage is, the more noticeable these side effects may be. For that reason, some doctors prescribe low dosages that are taken over a longer period of time.

  • Dryness of the skin and especially the lips, possibly leading to eczema or dermatitis
  • Dry eyes
  • Acne can worsen before improving
  • Nosebleeds from dry nasal mucosa
  • Bone, muscle, or joint pain (may be mild or severe)
  • Decreased night vision
  • Increased sun sensitivity
  • Increased muscle tenderness
  • Increased triglyceride levels in the blood

Severe Short-Term Side Effects

It's super important to regularly talk with your dermatologist while taking Accutane/isotretinoin. She can offer guidance for how to make the above side effects more tolerable and can adjust your dosage (or cease treatment) if any severe side effects manifest. With that said, here are some things to be on the look out for:

  • Pancreatitis: "This is a condition that occurs if lipids or fats, like triglyceride, increase in the blood and back up into the pancreas, causing pain and inflammation to the pancreas. Blood work is done to monitor lipids while on Accutane," said Dr. Gmyrek. Pancreatitis presents as sudden or ongoing pain in your abdomen or back. You may also feel bloated, nauseated, or experience vomiting, loss of appetite, and indigestion.
  • Liver damage and/or inflammation: "Patients are instructed not to drink alcohol while on the medication, and lab work monitors the liver during treatment," said Dr. Gmyrek. Liver damage doesn't often have obvious symptoms, but it's possible you may feel fatigued, experience some pain in your abdomen, or lose weight unexpectedly.
  • Changes in mood or behaviour/possible depression
  • Attempts at suicide or thoughts of suicide
  • Bone, muscle, or joint pain (may be mild or severe)
  • Severe malformations to a foetus if pregnancy occurs while taking the drug, or within four weeks of the last dose.

Severe Long-Term Side Effects

While the above side effects typically cease after treatment, you may experience some side effects that linger, or are permanent. Again, talk to your doctor if you experience any of these symptoms, and she can help you. Every person is different, and all treatments vary accordingly. The dermatologists we spoke to said that severe long-term side effects include the following:

  • Painful bone spurs
  • Closure of bone growth plates, which stops you from growing
  • Decreased vision in darkness, which may occur while on the drug and persist after the drug has been stopped
  • Hair loss or alopecia may occur while on the medication and may persist after discontinuation
  • Long-term malformations and effects to an infant born, if exposed in utero, to the drug via the mother's ingestion of the drug

Latent Side Effects

Latent side effects refer to issues triggered by your medication that aren't necessarily obvious to you. In fact, sometimes it can take months or years after treatment for these side effects to even be noticed! When we asked Dr. Gymrek about latent side effects of isotretinoin, here's what she said:

"It is unclear, and more data and study needs to be done, but it seems that Accutane/isotretinoin can cause the appearance of or worsening of inflammatory bowel disease in people who are predisposed to this disease," said Dr. Gmyrek. "I'm referring to patients who have a history of inflammatory bowel disease or a strong family history of inflammatory bowel disease."

Final Note

The side effects of Accutane/isotretinoin, like many medications, sound pretty scary. However, it has proven an effective treatment for those battling ongoing, severe acne who have run out of options. We recommend reading up on the drug, like you're already doing, and scheduling an appointment with a dermatologist for a more personalised review of what this treatment can do for you.

Image Source: iStock
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