Skip Nav
Best Way to Lose Weight and Keep It Off
Weight Loss
Forget Crash Diets: These Are the Habits That Will Help You Shed Those Pounds For Good
30-Minute No-Equipment Abs and Butt-Toning Workout
Workouts
Build Your Curves With This Ab and Booty Workout — No Equipment Needed
What Happens When You Stop Eating Bread?
Healthy Living
I Was Addicted to Bread; Here's What Happened When I Stopped Eating It For 1 Month
Sweat Trainer Says to Stop Weighing Yourself
Weight Loss
This Sweat Trainer Wants You to Ditch Your Scale and Do This Instead
Weight Loss
These Experts Reveal How to Lose Fat With Diet, Since Weight Loss Is 80% What You Eat

High-Fat Diet Hunger Study

New Research Suggests a High-Fat Diet Actually Makes It Harder to Feel Full


One of the benefits of eating a high-fat, low-carb diet — besides the weight loss — is that fat is a satiating macronutrient. Loading up on healthy monounsaturated fats such as avocados, nuts, and olive oil keeps you feeling satisfied until your next meal. But a new study suggests that eating high-fat foods actually blocks the brain from letting it know it's time to stop eating.

The research, published in Science Translational Medicine, found that mice that were fed a high-fat diet produce a hormone called MMP-2 that clips receptors for the hormone leptin in the brain, according to the EurekAlert release. Often referred to as the satiety hormone, leptin's job is to inform the brain that you have enough fat stored and are sated. Since MMP-2 blocks leptin from binding to its receptors, your brain doesn't get the signal that your stomach is full and you should stop eating. Researchers believe this mechanism explains a condition called leptin resistance, which is common among obese patients but isn't well understood. They also found when MMP-2 is blocked, the leptin can still signal when the stomach is full.

It's important to note that this study was conducted in mice, not humans. The type of fat the mice were fed also wasn't specified in the press release, whether it was healthy fats including monounsaturated fats or unhealthier ones such as saturated or trans fats. While scientists are continuing to study the phenomenon of leptin resistance, they are hoping for a clinical trial to test if MMP-2 blockers could actually help people lose weight.

In the meantime, check with your doctor or registered dietitian before making any major dietary changes. High-fat diets, such as the keto diet, should be done under medical supervision.

More from POPSUGAR
From Our Partners
What Kind of Bread Can You Eat on the Mediterranean Diet?
Does Intermittent Fasting Cause Headaches?
Overeating on Keto
Should I Cut Sugar to Lose Weight?
How Do I Lose Body Fat With Diet?
Trainer's Advice on Losing Belly Fat
How Do I Stay on Track With Eating Healthy?
Is the Mediterranean Diet Low-Carb?
Does Intermittent Fasting Boost Metabolism?
How Much Cardio to Lose Belly Fat?
Best Way to Lose Weight and Keep It Off
Sweat Trainer Says to Stop Weighing Yourself
From Our Partners
Latest Health & Fitness
All the Latest From Ryan Reynolds